Can Statins Cause Brain Fog?
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Cholesterol is a waxy, fat-like substance that flows through your bloodstream. Youâre at risk for a heart attack or stroke if your cholesterol numbers arenât good. Statins might help. Thatâs a class of drugs designed to lower your bodyâs level of low-density lipoprotein (LDL) cholesterol, also known as âbadâ cholesterol.
Statins and Brain Fog
While statins have a lot of health benefits and are safe for most people to use, there are some side effects. These can include:
Brain fog is âa general level of confusion and disorientation,â says Robert Rosenson, MD, director of the Cardiometabolic Unit at Mount Sinai Hospital in New York City.
The FDA approved label changes for statins that list memory loss and confusion as a ânon-serious and reversible side-effect.â
Cholesterol is an important part of your brain. In fact, 25% of the bodyâs cholesterol is found there. So it may seem like statins could affect how your brain works.
But experts donât think thereâs cause for concern. Several studies on the drugâs side effects suggest thereâs no direct link. And the symptoms could be a sign of other problems, Rosenson says.
âThey forget where they put their keys down, they may open the refrigerator, put the keys in there, [and] they forget and canât find them. But these are often signs of Alzheimerâs. And Alzheimerâs is a disease that develops over a long term,â he says.
These types of memory issues usually happen to people who are middle-age or older and can be a sign of many conditions.
âOne might need to ask the question: âIs it really the drug?â Or is there something else going on here that would require formal evaluation with a neuropsychiatric specialist,â Rosenson says.
On the flip side, some research suggests statin use is linked to lowering the risk of dementia or improving brain function. A 12-year study in Taiwan looked at 57,669 people over the age of 65 and found that high statin doses were âparticularly effectiveâ in preventing dementia. More research needs to be done on this.
What to Do if You Have Brain Fog
Donât stop taking your medication without talking to the doctor first. They may choose to:
- Stop your statin therapy
- Switch you to another type of statin
- Lower your dose
Rosenson says he may switch someone to a non-statin drug like ezetimibe. It works by absorbing the cholesterol in your intestine. Or he might try a PCSK9 inhibitor. Itâs a class of drugs that donât cross the blood-brain barrier. They break down LDL receptors and clear bad cholesterol from the bloodstream.
Currently, the FDA has approved two PCSK9 inhibitors for use. They are:
- Alirocumab (Praluent)
- Evolocumab (Repatha)
But Rosenson stresses that when it comes to statin therapy, the side effects like brain fog are rare and usually short-term. The pros often outweigh the cons, especially for people with high cholesterol or those at risk for:
âYou have to realize that there are not many drugs that can both reduce inflammation in the arteries and lower cholesterol,â he says. âSo, one has to think of the big picture and the extensive data.â
Things to Be Aware of When Youâre on Statins
Here are a few things to keep in mind to avoid or ease side effects:
Be careful with grapefruit. The juice contains certain chemicals that may interrupt how statins metabolize in your gut. While you donât have to give up grapefruit, ask your doctor what amount is safe to eat or drink.
Tell your doctor about all the medications youâre on. Certain drugs can interact with statins and may cause side effects. These include:
Take it easy when you exercise. One of the common side effects of statins is muscle aches and pain. But too much exercise can raise your risk for muscle injury or make it worse. If youâre starting a new exercise routine, build up the intensity slowly.
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